Gender differences in upper airway compliance during NREM sleep: role of neck circumference
Gender differences in upper airway compliance during NREM sleep: role of neck circumference
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DOI：
10.1152/japplphysiol.00553.2001
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发表时间：
2002-06-01
影响因子：
3.3
通讯作者：
Badr, MS
中科院分区：
文献类型：
--
作者：
Rowley, JA;Sanders, CS;Badr, MS
有研究认为，睡眠呼吸暂停患病率的性别差异与上呼吸道结构和功能的性别差异有关。我们假设与女性相比，男性的腭后横截面积更小，睡眠时的依从性更高。使用上呼吸道成像，我们测量了15名男性和15名女性在清醒和非快速眼动（NREM）睡眠时的上呼吸道横截面积和腭后顺应性。在清醒状态[194.5 +/- 21.3 vs. 138.8 +/- 12.0 (SE) mm(2)]和非快速眼动睡眠状态（111.1 +/- 17.6 vs. 83.3 +/- 11.9 mm）时，男性灵感开始时的横截面积均大于女性；P = 0.058)。但经体表面积校正后，两组间无显著差异。在两种清醒状态下，男性的后腭顺应性也趋于更高(5.9 +/- 1.4 vs. 3.1 +/- 1.4 mm(2)/cmH(2)O；P = 0.006)和NREM睡眠(12.6 +/- 2.7 vs. 4.7 +/- 2.6 mm(2) /cmH(2)O；P = 0.055)。然而，在矫正颈围后，男性和女性的依从性相似。我们得出结论，腭后依从性的性别差异更准确地归因于性别之间颈围的差异。
It has been proposed that the gender difference in sleep apnea prevalence is related to gender differences in upper airway structure and function. We hypothesized that men would have smaller retropalatal cross-sectional area and higher compliance during sleep compared with women. Using upper airway imaging, we measured upper airway cross-sectional area and retropalatal compliance in wakefulness and non-rapid eye movement (NREM) sleep in 15 men and 15 women without sleep-disordered breathing. Cross-sectional area at the beginning of inspiration tended to be larger in men compared with women in both wakefulness [194.5 +/- 21.3 vs. 138.8 +/- 12.0 (SE) mm(2)] and NREM sleep (111.1 +/- 17.6 vs. 83.3 +/- 11.9 mm(2); P = 0.058). There was no significant difference, however, after correction for body surface area. Retropalatal compliance also tended to be higher in men during both wakefulness (5.9 +/- 1.4 vs. 3.1 +/- 1.4 mm(2)/cmH(2)O; P = 0.006) and NREM sleep (12.6 +/- 2.7 vs. 4.7 +/- 2.6 mm(2) /cmH(2)O; P = 0.055). However, compliance was similar in men relative to women after correction for neck circumference. We conclude that the gender difference in retropalatal compliance is more accurately attributed to differences in neck circumference between the genders.