Preparation of a fluorous chiral BINOL derivative and application to an asymmetric protonation reaction
Preparation of a fluorous chiral BINOL derivative and application to an asymmetric protonation reaction
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DOI：
10.1016/s0040-4020(99)01004-2
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发表时间：
2000-01-14
期刊：
影响因子：
2.1
通讯作者：
Curran, DP
中科院分区：
文献类型：
--
作者：
Nakamura, Y;Takeuchi, S;Curran, DP
在烯醇钐的对映选择性质子化中，含氟手性质子源 (R,S)-FDHPEB 比原始非含氟 (R,S)-DHPEB (87% ee) 具有更高的对映选择性 (95% ee)。 (R,S)-FDHPEB 通过含氟反相硅胶的简单过滤即可轻松回收，并且可回收利用。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
Fluorous Chiral Proton Source (R,S)-FDHPEB resulted in a higher enantioselectivity (95% ee) than that of the original nonfluorous (R,S)-DHPEB (87% ee) in an enantioselective protonation of a samarium enolate. (R,S)-FDHPEB was easily recovered by a simple filtration through a fluorous reverse phase silica gel and was recyclable. (C) 2000 Elsevier Science Ltd. All rights reserved.