Brain mechanisms of conditioned taste aversion learning: A review of the literature
Brain mechanisms of conditioned taste aversion learning: A review of the literature
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条件性味觉厌恶学习的大脑机制：文献综述
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
K. E. Gaston
中科院分区：
文献类型：
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作者：
K. E. Gaston
动物似乎天生就倾向于将与食物有关的刺激（如味觉）与内部后果（如疾病）联系起来。这种味觉厌恶学习的神经机制知之甚少，但最近已经成为增加实验审查的对象。本文综述了几十篇关于中枢神经系统操作对味觉厌恶获得和保持的影响的报道。总的来说，证据表明，味觉厌恶学习，与传统的被动回避相比，是不寻常的抗干扰。下丘脑外侧和腹内侧以及杏仁核一直参与味觉厌恶学习，尽管它们的确切作用尚不清楚。处理其他结构的研究结果是矛盾和不确定的。讨论了导致这种混乱的方法论问题，并指出了进一步研究的潜在有益方向。
Animals appear to be innately predisposed to associate such food-related stimuli as taste with internal consequences, such as illness. The neural mechanisms of this taste aversion learning are poorly understood, but have recently been the object of increased experimental scrutiny. This article reviews several dozen published reports concerning the effects of central nervous system manipulations on acquisition and retention of taste aversions. Overall, the evidence indicates that taste aversion learning, as contrasted with traditional passive avoidance, is unusually resistant to disruption. The lateral and ventromedial hypothalamus and the amygdala are consistently implicated as participants in taste aversion learning, although their precise role is unclear. Results of studies dealing with other structures are contradictory and inconclusive. Methodological problems contributing to this confusion are discussed, and potentially profitable directions for further research are indicated.