Additively Manufactured Ferroelectric Particulate Composites for Antimicrobial Applications
Additively Manufactured Ferroelectric Particulate Composites for Antimicrobial Applications
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DOI：
10.1002/admt.202202127
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发表时间：
2023-03
影响因子：
6.8
通讯作者：
Z. Tsikriteas;R. Heylen;S. Jindal;E. Mancuso;Zihe Li;H. Khanbareh
中科院分区：
文献类型：
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作者：
Z. Tsikriteas;R. Heylen;S. Jindal;E. Mancuso;Zihe Li;H. Khanbareh
极化的铁电材料可以引发水分子的微电解，这导致在水溶液中形成活性氧（ROS），从而导致选择性的细菌杀灭。本研究提出极化铁电微粒复合材料之制造、表征及抗菌性能。锆钛酸钙钡（BCZT）微粉通过固态反应合成，并与聚己内酯（PCL）机械混合，随后送入3D生物打印机，以四种不同的陶瓷负载量（0、10、20、30重量%）制造多孔PCL-BCZT结构。为了检验材料处理极高污染的能力，将复合材料暴露于高接种量的细菌（大肠杆菌ATCC 25922），其为大肠杆菌的70%。在15分钟结束时记录大肠杆菌降解，没有任何外部干预。表面选择性细菌降解可归因于所产生的活性氧物质、多孔样品的大表面积和聚合物基质的疏水性质，其行为可反映在具有30重量%BCZT负载的复合材料中，该复合材料在其他最先进的铁电体中表现出最佳的抗微生物性能。总之，这些结果表明，极化复合材料具有很大的潜力，作为抗菌材料和表面。
A polarized ferroelectric material can initiate the micro‐electrolysis of water molecules which leads to the formation of reactive oxygen species (ROS) in an aqueous solution resulting in selective bacteria killing. This study presents the fabrication, characterization, and antimicrobial performance of poled ferroelectric particulate composites. Barium calcium zirconate titanate (BCZT) micro‐powder is synthesized by a solid‐state reaction and mechanically mixed with polycaprolactone (PCL) to be subsequently fed into the 3D bioprinter for the fabrication of porous PCL‐BCZT structures at four different ceramic loadings (0, 10, 20, 30 wt%). For the examination of material's capacity to handle extremely high contamination, the composites are exposed to a high inoculum of bacteria (Escherichia coli ATCC 25922) ≈70% of E. coli degradation is recorded at the end of 15 min without any external intervention. The surface selective bacterial degradation can be attributed to the generated reactive oxygen species, the large surface area of the porous samples and polymer matrix's hydrophobic nature, behavior which can be reflected in the composites with 30 wt% of BCZT loading exhibiting the best antimicrobial performance among the other state‐of‐the‐art ferroelectrics. Overall, these results indicate that the poled composites have a great potential as antimicrobial materials and surfaces.