Introduction of Aedes aegypti mosquitoes carrying wAlbB Wolbachia sharply decreases dengue incidence in disease hotspots.
Introduction of Aedes aegypti mosquitoes carrying wAlbB Wolbachia sharply decreases dengue incidence in disease hotspots.
复制标题
携带 wAlbB 沃尔巴克氏体的埃及伊蚊的引入大大降低了疾病热点地区的登革热发病率。
DOI：
10.1016/j.isci.2024.108942
复制
发表时间：
2024
期刊：
影响因子：
5.8
通讯作者：
Hoffmann AA
中科院分区：
文献类型：
--
作者：
Hoffmann AA
用携带某些遗传Wolbachiasymbionts菌株的外来蚊子部分取代埃及伊蚊，可以阻断登革热和其他对公共卫生有重要意义的病毒的传播。Wolbachiasymbionts是一种有效的传播阻断剂，在高温下稳定，特别适用于炎热的热带气候。在马来西亚进行试验性田间释放后，使用wAlbBAe进行释放。埃及人已经被马来西亚卫生当局运作起来。我们在这里报告的登革热平均减少62.4%（置信区间50-71%），在20个释放点相比，在高层住宅区的76个控制点。重要的是，随着沃尔巴克氏体的增加，登革热的减少水平增加，估计在100%沃尔巴克氏体时减少75.8%（61-87%）。这些发现表明wAlbBWolbachiainvasions在操作环境中对登革热发病率的影响很大，随着更广泛的地区被入侵，发病率预计将进一步下降。
Partial replacement of residentAedes aegyptimosquitoes with introduced mosquitoes carrying certain strains of inheritedWolbachiasymbionts can result in transmission blocking of dengue and other viruses of public health importance.WolbachiastrainwAlbB is an effective transmission blocker and stable at high temperatures, making it particularly suitable for hot tropical climates. Following trial field releases in Malaysia, releases usingwAlbBAe. aegyptihave become operationalized by the Malaysian health authorities. We report here on an average reduction in dengue fever of 62.4% (confidence intervals 50–71%) in 20 releases sites when compared to 76 control sites in high-rise residential areas. Importantly the level of dengue reduction increased withWolbachiafrequency, with 75.8% reduction (61–87%) estimated at 100%Wolbachiafrequency. These findings indicate large impacts ofwAlbBWolbachiainvasions on dengue fever incidence in an operational setting, with incidence expected to further decrease as wider areas are invaded.