Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat.
Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat.
复制标题
热损伤会导致大鼠局部肌肉而不是远处肌肉对 d-管箭毒碱产生更大的抵抗力。
DOI：
10.1097/00000539-200011000-00036
复制
发表时间：
2000
影响因子：
5.7
通讯作者：
Martyn,JA
中科院分区：
文献类型：
--
作者：
Ibebunjo,C;Martyn,JA
We tested the hypothesis that resistance to d-tubocurarine (dTC) is more intense in muscles closer to, than distant from, burn, and is related to the expression of immature and total acetylcholine receptors (AChRs). Anesthetized rats received approximately 4% surface area burn over the tibialis muscle of one leg with the contralateral leg serving as control, or approximately 45% of the flank burn, with sham-burned pair fed controls. At 1, 4, 7, or 14 days later, the 50% effective dose of dTC, membrane AChRs, and messenger ribonucleic acid (mRNA) that encode the AChR γ-subunit (AChRγ-mRNA) were quantified in the tibialis. After the local leg burn, AChRs increased at Days 4, 7, and 14, and AChRγ-mRNA at Days 4 and 7 after burn. The increased AChRγ-mRNA correlated with total AChRs (r= 0.82), suggesting that the up-regulated AChRs may contain the immature isoform. The 50% effective dose of dTC after the local leg burn increased 1.2-to 1.5-fold at all periods and correlated significantly with AChRs (r= 0.54) and AChRγ-mRNA (r= 0.57). After the flank burn, resistance was seen at Day 14 in association with muscle atrophy; AChRs and AChRγ-mRNA were unaltered. The resistance to dTC after a local burn occurs sooner, is more marked, and is probably related to both increases and isoform changes in AChRs. The resistance at distant muscles appears unrelated to AChR changes.ImplicationsThe resistance to d-tubocurarine after a burn differs between muscles near and distant from the burn and seems to depend on quantitative and qualitative changes in acetylcholine receptors and muscle atrophy associated with the insult.
