EFFECTS OF X-RAYS ON PROLIFERATION DYNAMICS OF CELLS IN IMAGINAL WING DISK OF DROSOPHILA-MELANOGASTER
EFFECTS OF X-RAYS ON PROLIFERATION DYNAMICS OF CELLS IN IMAGINAL WING DISK OF DROSOPHILA-MELANOGASTER
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DOI：
10.1007/bf00848779
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
BRYANT, PJ
中科院分区：
文献类型：
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作者：
HAYNIE, JL;BRYANT, PJ
用不同剂量的X射线照射72 h龄的D.幼虫辐射显著减少了成虫翅盘中进行正常增殖的细胞数量。1000 r的剂量减少了40-60%的细胞数量能够作出正常的贡献，成人翅膀的发展。这种减少的一部分是由于细胞的增殖能力，但仍然能够成人分化严重削减;这种影响可能是由于辐射诱导的非整倍体。细胞学证据表明，直接细胞死亡也发生作为辐射剂量低至100 r。存活的细胞被刺激以响应X射线损伤而进行额外的增殖，使得结果是正常翅膀的分化。
The size distribution of clones marked by mitotic recombination induced by several different doses of X-rays applied to 72 h old D. [melanogaster] larvae. The radiation significantly reduced the number of cells which underwent normal proliferation in the imaginal wing disc. A dose of 1000 r reduced by 40-60% the number of cells capable of making a normal contribution to the development of the adult wing. Part of this reduction was due to severe curtailment in the proliferative ability of cells which nevertheless remained capable of adult differentiation; this effect was possibly due to radiation-induced aneuploidy. Cytological evidence suggests that immediate cell death also occurred as a result of radiation doses as low as 100 r. The surviving cells were stimulated to undergo additional proliferation in response to the X-ray damage so that the result was the differentiation of a normal wing.