Measurement of electrical potentials of the human rectum and pelvic colon in normal and aldosterone-treated patients
Measurement of electrical potentials of the human rectum and pelvic colon in normal and aldosterone-treated patients
复制标题
正常和醛固酮治疗患者的人体直肠和盆腔结肠电位的测量
作者：
C. Edmonds;R. Godfrey
描述了一种方法，其允许在常规乙状结肠镜检查期间进行跨结肠粘膜上皮的电势差的快速测量。在27名肠正常的受试者中，测量的电位差平均值为25 mV（范围4至51 mV）。两次静脉注射0.5 mg醛固酮后6小时，电位差上升至60 mV（范围37 - 101 mV）。单次注射醛固酮后研究的反应时间过程表明，潜在的允许量在4小时内上升，18小时后再次下降。尿钠浓度和钠/钾比值下降醛固酮注射后，变化的时间过程是类似的结肠电位差。大便钠浓度也下降。根据电化学梯度，粪便液中氯化物的浓度与氯化物的被动分布一致，但钾的浓度远高于被动分布的预期，表明钾被主动分泌到结肠腔中。
A method is described which allows rapid measurement of the electrical potential difference across colonic mucosal epithelium to be carried out during routine sigmoidoscopy. The potential differences measured had a mean value of 25 mV (range 4 to 51 mV) in 27 subjects with normal bowel. Six hours after two intravenous injections of 0·5 mg aldosterone the potential difference had risen to 60 mV (range 37 to 101 mV). The time course of responses studied after a single injection of aldosterone showed that the potential allowance rose within four hours and had fallen again after 18 hours. Urinary sodium concentrations and sodium/potassium ratios fell after aldosterone injections, the time course of the changes being similar to that of the potential differences of the colon. Sodium concentration of stool fluid also fell. The concentration of chloride in the stool fluid was consistent with a passive distribution of chloride according to the electrochemical gradient, but that of potassium was considerably greater than expected from a passive distribution, suggesting that potassium is actively secreted into the lumen of the colon.