Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures.
Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures.
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DOI：
10.1016/j.neuroimage.2015.10.010
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发表时间：
2016-01-15
期刊：
影响因子：
5.7
通讯作者：
Brain Development Cooperative Group
中科院分区：
文献类型：
--
作者：
Ducharme S;Albaugh MD;Nguyen TV;Hudziak JJ;Mateos-Pérez JM;Labbe A;Evans AC;Karama S;Brain Development Cooperative Group
一些报告描述了皮质厚度（CTh）的发展轨迹，结果相互矛盾。一些研究报道了CTh的倒U形曲线，在儿童晚期到青春期达到峰值，而另一些研究则表明6岁后主要呈单调下降。在这项研究中，我们回顾了NIH MRI研究正常脑发育中的CTh发育轨迹，并在第二步中评估了后处理质量控制（QC）程序对已识别轨迹的影响。质量控制样本包括384名年龄为4.9至22.3岁的重复扫描（每名受试者1-3次，总扫描n=753）的个体受试者。使用混合效应模型在每个顶点确定最佳拟合模型（三次、二次或一阶线性）。大部分脑区CTh呈线性单调下降。有几个领域的立方轨迹，主要是在双边颞顶叶区和右前额叶皮层，其中CTh峰值是在8岁或之前。当控制总脑体积时，CTh轨迹甚至更均匀地呈线性。唯一的性别差异是男孩的枕骨区域比女孩更快变薄。全脑平均厚度的最佳拟合模型是每年0.027 mm的单调下降。QC程序对识别的轨迹有显著影响，当包括所有无QC的扫描时，明显向更复杂的轨迹转变（n=954）。当仅使用通过最严格QC的扫描时，轨迹几乎完全是线性的（n=598）。QC的影响可能与减少包含继发于运动伪影的CTh低估扫描有关，这在年轻受试者中更常见。总之，我们的研究结果表明，CTh遵循一个简单的线性下降，在大多数皮层地区的5岁，和所有地区的8岁。这项研究进一步支持了在CTh研究的发展，衰老和神经精神疾病的实施后处理QC的至关重要性。
Several reports have described cortical thickness (CTh) developmental trajectories, with conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in late childhood to adolescence, while others suggested predominant monotonic decline after age 6. In this study, we reviewed CTh developmental trajectories in the NIH MRI Study of Normal Brain Development, and in a second step evaluated the impact of post-processing quality control (QC) procedures on identified trajectories. The quality-controlled sample included 384 individual subjects with repeated scanning (1–3 per subject, total scans n=753) from 4.9 to 22.3 years of age. The best-fit model (cubic, quadratic, or first-order linear) was identified at each vertex using mixed-effects models. The majority of brain regions showed linear monotonic decline of CTh. There were few areas of cubic trajectories, mostly in bilateral temporo-parietal areas and the right prefrontal cortex, in which CTh peaks were at, or prior to, age 8. When controlling for total brain volume, CTh trajectories were even more uniformly linear. The only sex difference was faster thinning of occipital areas in boys compared to girls. The best-fit model for whole brain mean thickness was a monotonic decline of 0.027 mm per year. QC procedures had a significant impact on identified trajectories, with a clear shift toward more complex trajectories when including all scans without QC (n=954). Trajectories were almost exclusively linear when using only scans that passed the most stringent QC (n=598). The impact of QC probably relates to decreasing the inclusion of scans with CTh underestimation secondary to movement artifacts, which are more common in younger subjects. In summary, our results suggest that CTh follows a simple linear decline in most cortical areas by age 5, and all areas by age 8. This study further supports the crucial importance of implementing post-processing QC in CTh studies of development, aging, and neuropsychiatric disorders.