A simple coumarin-based system for the effective detection of superoxide in bacteria
A simple coumarin-based system for the effective detection of superoxide in bacteria
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DOI：
10.1016/j.rechem.2023.101244
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发表时间：
2023-12
影响因子：
2.3
通讯作者：
Kai-Cheng Yan;Qiao Cao;Naing Thet;A. Sedgwick;Tony D. James;A. T. A. Jenkins-A.-T.-A.-Jenkins-2256208663
中科院分区：
文献类型：
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作者：
Kai-Cheng Yan;Qiao Cao;Naing Thet;A. Sedgwick;Tony D. James;A. T. A. Jenkins-A.-T.-A.-Jenkins-2256208663
超氧阴离子是一种高度活性的ROS，然而这种物质的传感相对未被探索。目前检测超氧化物的方法需要构建复杂的探针，这些探针通常很难合成。通过这项研究，我们报告了一种简单的一步高产率（90%）的方法来制备用于检测O2的探针。在细菌中使用香豆素核心和三氟甲磺酸酯锁定基团。
Superoxide anion is a highly reactive ROS however the sensing of this species is relatively unexplored. The current methods to sense superoxide requires the construction of complex probes which are often hard to synthesize. With this research we report a simple one step high yielding (90%) method to prepare a probe for the detection of O2.-in bacteria using a coumarin core and trifluoromethanesulfonate locking group.