Evolution via somatic genetic variation in modular species.
Evolution via somatic genetic variation in modular species.
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DOI：
10.1016/j.tree.2021.08.011
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发表时间：
2021-09
影响因子：
16.8
通讯作者：
T. Reusch;I. Baums;B. Werner
中科院分区：
文献类型：
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作者：
T. Reusch;I. Baums;B. Werner
体细胞遗传变异（SoGV）在植物、动物和真菌中的长寿、模块化物种中可能起着重要但未被充分认识的作用。最近的基因组数据确定了两个层次的遗传异质性，细胞系之间和模块之间，受到多级选择。由于SoGV可以在个体发育后期（植物，藻类，真菌和一些基础动物）生殖系被隔离时转移到配子中，有性和无性过程提供了相互依赖的突变输入途径，并影响遗传负荷的积累和综合无性/有性生活周期的分子进化速率。未来研究的途径包括SoGV可能的适应性效应，多级选择的识别和影响，以及使用肿瘤进化方法进行无性选择性扫描的建模。
Somatic genetic variation (SoGV) may play a consequential yet underappreciated role in long-lived, modular species among plants, animals, and fungi. Recent genomic data identified two levels of genetic heterogeneity, between cell lines and between modules, that are subject to multilevel selection. Because SoGV can transfer into gametes when germlines are sequestered late in ontogeny (plants, algae, and fungi and some basal animals), sexual and asexual processes provide interdependent routes of mutational input and impact the accumulation of genetic load and molecular evolution rates of the integrated asexual/sexual life cycle. Avenues for future research include possible fitness effects of SoGV, the identification and implications of multilevel selection, and modeling of asexual selective sweeps using approaches from tumor evolution.