High expression of aldo-keto reductase 1B10 is an independent predictor of favorable prognosis in patients with hepatocellular carcinoma.
High expression of aldo-keto reductase 1B10 is an independent predictor of favorable prognosis in patients with hepatocellular carcinoma.
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高表达Aldo-Keto还原酶1B10是肝细胞癌患者有利预后的独立预测指标。
DOI：
10.5009/gnl13406
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发表时间：
2014-11
期刊：
影响因子：
3.4
通讯作者：
Park CK
中科院分区：
文献类型：
--
作者：
Ha SY;Song DH;Lee JJ;Lee HW;Cho SY;Park CK
通过有丝分裂激活蛋白-1信号通路上调醛酮还原酶1B10 （AKR1B10）可能促进肝癌的发生和肿瘤的进展。本研究的目的是评估AKR1B10蛋白表达在肝细胞癌患者术后的预后意义。采用组织微阵列技术检测255例行根治性肝切除术的肝癌患者肿瘤中AKR1B10蛋白的表达水平。分析AKR1B10表达对患者生存的影响。中位随访时间为119.8个月。255例肝细胞癌患者中有125例（49.0%）出现AKR1B10蛋白高表达。AKR1B10高表达与门静脉主干不受侵犯（p=0.022）、肝内不发生转移（p=0.010）、美国癌症联合委员会T分期（p=0.016）、巴塞罗那临床肝癌分期（p=0.006）和α-胎蛋白水平（p=0.020）降低显著相关。AKR1B10高表达也与缺乏早期复发相关（p=0.022）。多变量生存分析显示，肝内转移和较低的白蛋白水平是较短的无复发生存期和较短的疾病特异性生存期的独立预测因素。AKR1B10高表达是延长无复发生存期（p=0.024）和延长疾病特异性生存期（p=0.046）的独立预测因子。高AKR1B10蛋白表达可能是肝细胞癌根治性肝切除术后预后良好的标志。
Upregulation of aldo-keto reductase 1B10 (AKR1B10) through the mitogenic activator protein-1 signaling pathway might promote hepatocarcinogenesis and tumor progression. The goal of this study was to evaluate the prognostic significance of AKR1B10 protein expression in patients with hepatocellular carcinoma after surgery. A tissue microarray was used to detect the expression level of AKR1B10 protein in tumors from 255 patients with hepatocellular carcinoma who underwent curative hepatectomy. The impact of AKR1B10 expression on the survival of patients was analyzed. The median follow-up period was 119.8 months. High AKR1B10 protein expression was observed in 125 of the 255 patients with hepatocellular carcinoma (49.0%). High AKR1B10 expression was significantly associated with a lack of invasion of the major portal vein (p=0.022), a lack of intrahepatic metastasis (p=0.010), lower the American Joint Committee on Cancer T stage (p=0.016), lower the Barcelona Clinic Liver Cancer stage (p=0.006), and lower α-fetoprotein levels (p=0.020). High AKR1B10 expression was also correlated with a lack of early recurrence (p=0.022). Multivariate analyses of survival revealed that intrahepatic metastases and lower albumin levels were independent predictors of both shorter recurrence-free survival and shorter disease-specific survival. High AKR1B10 expression was an independent predictor of both longer recurrence-free survival (p=0.024) and longer disease-specific survival (p=0.046). High AKR1B10 protein expression might be useful as a marker of a favorable prognosis in patients with hepatocellular carcinoma after curative hepatectomy.
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影响因子：
2.3
作者：
Lee, KWY;Ko, BCB;Chung, SSM
通讯作者：
Chung, SSM
影响因子：
3.5
作者：
Liu Z;Zhong L;Krishack PA;Robbins S;Cao JX;Zhao Y;Chung S;Cao D
通讯作者：
Cao D
DOI：
10.1056/nejmoa0804525
发表时间：
2008-11-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hoshida Y;Villanueva A;Kobayashi M;Peix J;Chiang DY;Camargo A;Gupta S;Moore J;Wrobel MJ;Lerner J;Reich M;Chan JA;Glickman JN;Ikeda K;Hashimoto M;Watanabe G;Daidone MG;Roayaie S;Schwartz M;Thung S;Salvesen HB;Gabriel S;Mazzaferro V;Bruix J;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
11.5
作者：
Fukumoto, S;Yamauchi, N;Aburatani, H
通讯作者：
Aburatani, H
影响因子：
8.4
作者：
Yahagi, N;Shimano, H;Yamada, N
通讯作者：
Yamada, N