Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta-analysis
Prevalence of hypertriglyceridemic waist and association with risk of type 2 diabetes mellitus: a meta-analysis
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高甘油三酯腰围患病率及其与 2 型糖尿病风险的关联：一项荟萃分析
DOI：
10.1002/dmrr.2725
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发表时间：
2016-05-01
影响因子：
8
通讯作者：
Hu, Dongsheng
中科院分区：
文献类型：
--
作者：
Ren, Yongcheng;Luo, Xinping;Hu, Dongsheng
对高甘油三酯血症腰围及其与2型糖尿病(T2 DM)风险关系的研究进行荟萃分析。资料与方法检索PubMed、EMBASE、Web of Science、CNKI、CQVIP和万方数据库，检索高甘油三酯血症腰围及其与T2 DM风险关系的研究。还搜索了每一篇原始文章的参考文献列表。使用随机效应模型来综合患病率和优势比。结果25项符合条件的研究涉及93194名参与者(93194项为患病率，34199项为优势比)：17篇是关于患病率的文章，8篇是关于T2 DM患病率和风险的文章。腰部高甘油三酯血症的患病率从4%到47%不等，合并患病率为18%(95%可信区间13-23%)，总体上男性为18%(95%可信区间1323%)，女性为19%(95%可信区间1324%)。T2MD的总体优势比为2.8~9.6，合并优势比为4.18(95%可信区间3.55~4.92)，男性为3.55(95%可信区间2.93~4.31)，女性为4.18(95%可信区间3.43~5.09)。讨论/结论腰部高甘油三酯血症的患病率已达到令人担忧的水平，并与普通人群中T2 DM的风险增加密切相关，尤其是在女性和棕色皮肤男性和女性中。版权所有(C)2015 John Wiley&Sons，Ltd.
IntroductionA meta-analysis of studies assessing the prevalence of hypertriglyceridemic waist and an association with risk of type 2 diabetes mellitus (T2DM).Materials and methodsPubMed, EMBASE, Web of Science, CNKI, CQVIP and Wanfang databases were searched for studies of the prevalence of hypertriglyceridemic waist or association with risk of T2DM. Reference lists of each original article were also searched. A random-effects model was used to synthesize the combined prevalence and odds ratios. Publication bias and substantial heterogeneity were examined.ResultsTwenty-five eligible studies involving 93194 participants (93194 for prevalence and 34199 for odds ratios): 17 articles of prevalence, and 8 of both prevalence and risk of T2DM. Prevalence of hypertriglyceridemic waist ranged from 4% to 47%, with pooled prevalence of 18% (95% CI 13-23%), overall: 18% (95% CI 13-23%) for men and 19% (95% CI 13-24%) for women. Odds ratios ranged from 2.8 to 9.6 for T2MD in overall, with pooled odds ratios of 4.18 (95% CI 3.55-4.92), overall: 3.55 (95% CI 2.93-4.31) for men and 4.18 (95% CI 3.43-5.09) for women.Discussion/conclusionThe prevalence of hypertriglyceridemic waist has reached an alarming level and is closely associated with increased risk of T2DM in the general population, particularly among women and among brown-skinned men and women. Copyright (c) 2015 John Wiley & Sons, Ltd.