Avoidance of epimerization in the synthesis of peptide thioesters using Fmoc protection

Avoidance of epimerization in the synthesis of peptide thioesters using Fmoc protection
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DOI:
10.1055/s-2007-986631
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发表时间:
2007-10-01
期刊:
影响因子:
2
通讯作者:
Warriner, Stuart L.
Warriner, Stuart L.
中科院分区:
化学4区
文献类型:
--
作者:
Nagalingam, Anil C.;Radford, Sheena E.;Warriner, Stuart L.

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已开发出一种将受保护的肽转化为硫酯的有效程序,可显着减少 C 末端差向异构化的发生。
An efficient procedure for the conversion of protected peptides into thioesters has been developed which dramatically reduces the occurrence of C-terminal epimerization.