On Buckling Morphogenesis
On Buckling Morphogenesis
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DOI：
10.1115/1.4032128
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发表时间：
2016-02-01
影响因子：
1.7
通讯作者：
Nelson, Celeste M.
中科院分区：
文献类型：
--
作者：
Nelson, Celeste M.
细胞产生的机械力驱动许多组织运动和重排，这些运动和重排是将简单的细胞群转化为成熟器官的复杂三维几何形状所必需的。然而，机械力不需要来自活跃的细胞运动。最近的研究已经阐明了上皮组织与其周围环境之间的机械不稳定性所导致的被动力的作用。这些机械不稳定性基本上导致一维上皮管和二维上皮片弯曲或起皱成复杂的拓扑结构，包括脑、肠和肺等不同器官中的环、折叠和起伏。在这里，我强调的例子屈曲和弯曲的形态发生，并建议，这种形态发生机制可能是广泛负责雕塑器官的形式。
Cell-generated mechanical forces drive many of the tissue movements and rearrangements that are required to transform simple populations of cells into the complex three-dimensional geometries of mature organs. However, mechanical forces do not need to arise from active cellular movements. Recent studies have illuminated the roles of passive forces that result from mechanical instabilities between epithelial tissues and their surroundings. These mechanical instabilities cause essentially one-dimensional epithelial tubes and two-dimensional epithelial sheets to buckle or wrinkle into complex topologies containing loops, folds, and undulations in organs as diverse as the brain, the intestine, and the lung. Here, I highlight examples of buckling and wrinkling morphogenesis, and suggest that this morphogenetic mechanism may be broadly responsible for sculpting organ form.