Bone Morphogenetic Protein-2 Adsorption onto Poly-e-caprolactone Better Preserves Bioactivity In Vitro and Produces More Bone In Vivo than Conjugation Under Clinically Relevant Loading Scenarios
Bone Morphogenetic Protein-2 Adsorption onto Poly-e-caprolactone Better Preserves Bioactivity In Vitro and Produces More Bone In Vivo than Conjugation Under Clinically Relevant Loading Scenarios
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DOI：
10.1089/ten.tec.2014.0377
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发表时间：
2015-05-01
影响因子：
3
通讯作者：
Hollister, Scott J.
中科院分区：
文献类型：
--
作者：
Patel, Janki J.;Flanagan, Colleen L.;Hollister, Scott J.
背景：重建大骨缺损的一种策略是通过将带有相关生物制剂的生物材料支架植入背阔肌来预制一个带血管的皮瓣，然后在成熟期后将此构建体移植到缺损部位。这种策略与所有临床和监管上可行的用于手术重建的生物学方法类似，需要能够快速（
Background: One strategy to reconstruct large bone defects is to prefabricate a vascularized flap by implanting a biomaterial scaffold with associated biologics into the latissimus dorsi and then transplanting this construct to the defect site after a maturation period. This strategy, similar to all clinically and regulatory feasible biologic approaches to surgical reconstruction, requires the ability to quickly (