Pregnancy and Rheumatoid Arthritis: Insights into the Immunology of Fetal Tolerance and Control of Autoimmunity
Pregnancy and Rheumatoid Arthritis: Insights into the Immunology of Fetal Tolerance and Control of Autoimmunity
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DOI：
10.1007/s11926-011-0199-1
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发表时间：
2011-10-01
影响因子：
5
通讯作者：
Mueller, Daniel L.
中科院分区：
文献类型：
--
作者：
Amin, Shreyasee;Peterson, Erik J.;Mueller, Daniel L.
长期以来，人们一直认为，类风湿性关节炎(RA)的症状和体征经常在怀孕期间自发改善，只是在产后发作。尽管这一现象背后的机制仍然知之甚少，但人们对健康怀孕期间发生的免疫学变化越来越感兴趣，作为一种可能的解释。由于母体免疫系统必须在妊娠期间适应以接受半异基因胎儿，因此有人推测，妊娠对母体免疫调节细胞的这些自然变化可能具有控制RA疾病活动的免疫病理学的额外好处。在这里，我们回顾了目前对妊娠对类风湿性关节炎影响的认识，并重点介绍了一些与增进我们对妊娠免疫学以及妊娠期类风湿关节炎免疫学变化的理解相关的最新文献。
It has long been recognized that symptoms and signs of rheumatoid arthritis (RA) frequently improve spontaneously during pregnancy, only to flare postpartum. Although the mechanisms behind this phenomenon remain poorly understood, there is growing interest in the immunologic changes that occur during healthy pregnancy as a possible explanation. Because the maternal immune system must adapt during pregnancy to accept the semi-allogeneic fetus, it has been hypothesized that these natural changes induced by pregnancy on maternal immune regulatory cells may have the additional benefit of controlling the immunopathology driving disease activity in RA. Here, we review our current understanding on the effects of pregnancy on RA and highlight some of the recent literature related to advancing our understanding on the immunology of pregnancy as well as the immunologic changes in RA during pregnancy.