High-Frequency Stimulation for Parkinson's Disease and Effects on Pathways in Basal Ganglia Network Model
High-Frequency Stimulation for Parkinson's Disease and Effects on Pathways in Basal Ganglia Network Model
复制标题
帕金森病的高频刺激及其对基底神经节网络模型通路的影响
DOI：
10.1007/s40846-016-0170-8
复制
发表时间：
2016
影响因子：
2
通讯作者：
Zeng Yanjun
中科院分区：
文献类型：
--
作者：
Jiang Xiaofang;Liu Shenquan;Lu Bo;Zeng Yanjun
基底神经节核的脑深部刺激已被认为是帕金森病患者运动功能减退的最有效的神经外科治疗方法;然而，其疗效的机制仍不清楚。此外，基底神经节的两个主要通路对丘脑的已知作用可以为进一步探索和研究提供最佳靶点的信息。为了模拟高频刺激对帕金森病不同靶点的作用，基于解剖结构的生物学原理和电导模型，构建了皮质-基底-丘脑网络模型。以三个不同的核团区域为靶点，模拟分析了不同刺激持续时间和刺激周期对三个靶点的差异沿着刺激效能。然后，通过采用不同的刺激幅度，作用于三个目标，不同的刺激幅度和目标的治疗帕金森病的效果进行了比较分析。为了确定最佳靶点，计算了两种主要途径对丘脑的不同影响。计算结果表明，皮质-基底-丘脑网络是可靠的，通过使用可行的模型，高频刺激这三个靶点可以改善病理性丘脑节律性。结果表明，直接途径兴奋丘脑，而间接途径在丘脑中起着调节作用。
Deep brain stimulation of nuclei in the basal ganglia has been recognized as the most effective neurosurgical therapy for hypokinesia in patients with Parkinson’s disease; however, the mechanism underlying its curative effect remains unknown. In addition, the known effects of the two major pathways of the basal ganglia on the thalamus can offer information on optimal targets for further exploration and research. To simulate high-frequency stimulation to the different targets in Parkinson’s disease, a cortico-basal-thalamic network model was constructed based on the biological principles of anatomical structures and utilization of conductance-based models. Taking three different nucleus regions as targets, we simulated and analyzed the diversity of different stimulus durations and periods, along with stimulus efficacy, for the three targets. Then, by adopting different stimulus magnitudes that acted on the three targets, a comparative analysis of the effects of different stimulus magnitudes and targets for the treatment of Parkinson’s disease was performed. To identify the optimal target, different effects of the two major pathways on the thalamus were calculated. The calculation results show that the cortico-basal-thalamic network is reliable, and through the use of feasible models, high-frequency stimulation of the three targets can improve the pathological thalamic rhythmicity. It is shown that the direct pathway excites the thalamus, while the indirect pathway plays a regulatory role in the thalamus.