Targeting IRFs by ubiquitination: regulating antiviral responses
Targeting IRFs by ubiquitination: regulating antiviral responses
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DOI：
10.1042/bst0360453
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Jefferies, Caroline A.
中科院分区：
文献类型：
--
作者：
Higgs, Rowan;Jefferies, Caroline A.
IRF [IFN（干扰素）调节因子]转录因子家族控制许多细胞过程，包括病毒感染后诱导关键的抗病毒细胞因子I型IFN。最近的研究揭示了几种内源性和病毒蛋白参与泛素介导的IRF活性调节，从而对I型IFN信号传导产生影响。通过泛素途径，这些蛋白质可以通过启动IRF的蛋白酶体降解或相反地通过促进IRF的活化来操纵抗病毒应答。
The IRF [IFN (interferon) regulatory factor] family of transcription factors control many cellular processes, including induction of key antiviral cytokines, type I IFNs, following viral infection. Recent studies have revealed several endogenous and viral proteins involved in ubiquitin-mediated regulation of IRF activity and thus having an impact on type I IFN signalling. Through the ubiquitin pathway, these proteins can manipulate the antiviral response either by initiating proteasomal degradation of the IRFs or, in contrast, by promoting activation of the IRFs.