Reproducibility of proton magnetic resonance spectroscopy imaging measurements of normal human hippocampus at 1.5 T: clinical implications.
Reproducibility of proton magnetic resonance spectroscopy imaging measurements of normal human hippocampus at 1.5 T: clinical implications.
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1.5 T 下正常人海马质子磁共振波谱成像测量的再现性：临床意义。
DOI：
10.1111/j.1552-6569.2001.tb00033.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Kuzniecky,R
中科院分区：
文献类型：
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作者：
Maton,B;Londono,A;Sawrie,S;Knowlton,R;denHollander,J;Kuzniecky,R
作者研究了用质子磁共振波谱(1H-MRS)测量的代谢物信号在对照组和模体中的重复性。在8名健康志愿者和一个模体中进行了间隔3周的两次H-MRS研究。测量N-乙酰基化合物(NA)、胆碱(CH)和肌酸(Cr)峰的面积和比率，用百分比变异和皮尔逊相关系数在每个体素水平、1个海马区(5个体素)和2个海马区(10个体素)水平进行比较。使用可靠的变化指数来评估观察两次会议之间有临床意义的1H-MRS变化的敏感性。代谢物峰面积的重现性测量仅与NA、ChO和Cr的百分比差异在14%到20%之间保持中等一致性。当考虑NA比率和多个体素之和时，稳定性得到了很大的改善。当分别考虑单体素水平、单个海马区水平或两个海马区水平时，在给定参与者中，会话间NA/(Cho+Cr)大于22%、12%和10%的变化可以以90%的可信区间被检测到。左右不对称指数在重复检查中表现为相似的、有限的大脑半球间不对称。这项研究表明，当考虑NA比率和多个体素的总和时，1H-MRS的重复性性能足以用于人类海马区功能的研究和监测。单独的代谢物峰和单体素测量在1.5T时的重复性较低，应仅在明确确定的统计参数下使用。
The authors investigate the reproducibility of metabolite signals measured with proton magnetic resonance spectroscopy1H‐MRS) acquired from the human hippocampus in controls and in a phantom. Two1H‐MRS studies separated by 3 weeks were performed in 8 healthy volunteers and in a phantom. N‐acetyl compounds (NA), choline (Ch), and creatine (Cr) peak areas and ratios were measured and compared using percentage variation, and Pearson Correlation Coefficient at the level of every voxel, the level of 1 hippocampus (5 voxels), and the level of 2 hippocampi (10 voxels). Sensitivity for observing clinically significant between‐session1H‐MRS changes was evaluated using the reliable change index. Reproducibility measures for metabolite peak areas were only moderately concordant with percentage variation ranging from 14% to 20% for NA, Cho, and Cr. Stability was much improved when NA ratios and sum of multiple voxels were considered. Between‐session NA/(Cho + Cr) changes greater than 22%, 12%, and 10% in one given participant can be detected with a 90% confidence interval when considered at the single‐voxel level, the level of a single hippocampus, or the level of both hippocampi, respectively. Left‐right asymmetry indices showed similar and limited interhemispheric asymmetry in repeated examination. This study suggests that1H‐MRS reproducibility performance is adequate for the study and monitoring of human hippocampus function when NA ratios and the sum of multiple voxels are considered. Individual metabolite peaks and single‐voxel measurements have low reproducibility at 1.5 T and should be used only with clearly established statistical parameters.