Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator
Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator
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DOI：
10.1039/b611078a
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Komiyama, Makoto
中科院分区：
文献类型：
--
作者：
Asanuma, Hiroyuki;Hayashi, Hiroyuki;Komiyama, Makoto
通过在10-23DNAzyme的催化环与结合臂的连接处引入D-苏氨酸嵌入剂，大大提高了RNA的切割活性。
By introducing an intercalator through D-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.