High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma
High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma
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DOI：
10.1245/s10434-012-2593-y
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发表时间：
2013-02-01
影响因子：
3.7
通讯作者：
Fang, Hsin-Yi
中科院分区：
文献类型：
--
作者：
Jeng, Kuo-Shyang;Sheen, I-Shyan;Fang, Hsin-Yi
肝细胞癌（HCC）切除后复发率高。已有研究表明，声刺猬（SHH）信号通路的异常激活与某些器官的癌变有关。在一项前瞻性研究中，从2006年1月至2010年6月，共有50例连续的肝癌根治性切除术后患者入选。检测肝癌组织与癌旁肝组织中SHH、PTCH-1和GLI-1的mRNA表达的比值。比较复发组与未复发组的临床病理特征及上述比值。PTCH-1 mRNA表达与血清AFP水平（p = 0.045）、肿瘤大小（p = 0.001）、血管浸润（p = 0.043）和肿瘤、淋巴结、转移分期（TNM分期）（p = 0.003）相关。GLI-1 mRNA的比值与肿瘤大小（p = 0.062）和TNM分期（p = 0.051）之间存在临界显著相关性。SHH mRNA与各参数间均无显著相关性。PTCH-1 mRNA和GLI-1 mRNA的比值均显著影响复发（分别为p = 0.003和0.005）和生存（分别为p < 0.001和< 0.001）。
Hepatocellular carcinoma (HCC) has a high recurrence rate after resection. Abnormal activation of the sonic hedgehog (SHH) signaling pathway contributing to the carcinogenesis of some organs had been reported. We hypothesize that activation of SHH pathway contributes to the recurrence of HCC after surgical resection.In a prospective study, from January 2006 to June 2010, a total of 50 consecutive patients with HCC after curative resection were enrolled. The ratio of the expression of messenger RNA (mRNA) of SHH, patched homolog-1 (PTCH-1) and glioma-associated oncogene-1 (GLI-1) between HCC tissues and the paired noncancerous liver tissues were measured. Both the clinicopathologic characteristics and these ratios were compared between those with recurrence and those without recurrence. They were also compared between those with and without survival.There was a statistically significant correlation among the ratios of PTCH-1 mRNA and serum AFP level (p = 0.045), tumor size (p = 0.001), vascular permeation (p = 0.043) and tumor, node, metastasis staging system (TNM) stage (p = 0.003). A borderline significant correlation was found among ratios of GLI-1 mRNA and tumor size (p = 0.062) and TNM stage (p = 0.051). There was no such significant correlation between SHH mRNA and any parameter. Both the ratios of PTCH-1 mRNA and GLI-1 mRNA significantly adversely affected recurrence (p = 0.003 and 0.005, respectively) and survival (p < 0.001 and < 0.001, respectively).Expression of PTCH-1 mRNA and GLI-1 mRNA in HCC tissues is a potential biomarker to predict postresection disease recurrence.