Tooth morphogenesis and cell differentiation
Tooth morphogenesis and cell differentiation
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DOI：
10.1016/s0955-0674(96)80086-x
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发表时间：
1996-12-01
影响因子：
7.5
通讯作者：
Nieminen, P
中科院分区：
文献类型：
--
作者：
Thesleff, I;Nieminen, P
牙齿是脊椎动物器官之一，人们开始了解其分子水平的发育。已鉴定出分泌的信号分子介导牙上皮和间充质之间连续的酸交互诱导相互作用。已发现转录因子参与这些信号级联。最近在牙釉质结中发现了一个信号或组织中心，它表达与胚胎中其他组织中心相同的信号，并且可能调节牙齿形状。最近发现，哺乳动物牙齿发育过程中起作用的信号网络与其他脊椎动物器官发育过程中所涉及的信号网络相似。
The tooth is one of the vertebrate organs in which development at the molecular level is beginning to be understood. Secreted signaling molecules have been identified that mediate sequential acid reciprocal inductive interactions between the dental epithelium and mesenchyme. Transcription factors have been found that participate in these signaling cascades. A signaling or organizing center was recently discovered in the dental enamel knot that expresses the same signals as other organizing centers in the embryo, and which presumably regulates tooth shape. It has recently become evident that the signaling networks that operate in the development of mammalian teeth are similar to those that are involved in the development of other vertebrate organs.