Insulin-Degrading Enzyme: A Link Between Alzheimer's and Type 2 Diabetes Mellitus
Insulin-Degrading Enzyme: A Link Between Alzheimer's and Type 2 Diabetes Mellitus
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DOI：
10.2174/18715273113126660139
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发表时间：
2014-01-01
影响因子：
3
通讯作者：
Nazir, Aamir
中科院分区：
文献类型：
--
作者：
Haque, Rizwanul;Nazir, Aamir
酶在维持体内的动态平衡方面起着至关重要的作用。酶的功能不正常与许多疾病有关。胰岛素降解酶(IDE)是一种普遍表达的锌金属蛋白酶，被认为是2型糖尿病和阿尔茨海默病的连接点。最近的研究为IDE作为潜在靶点的使用提供了线索，因此其调节剂的设计将是治疗这些疾病的可行方法。本文综述了IDE的结构和功能，描述了IDE、2型糖尿病和阿尔茨海默病之间的关系，并讨论了使IDE成为潜在靶点的途径。
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer's disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer's disease and the approaches that make IDE a potential target, are discussed.