Multidomain and ground state configurations of two-phase vesicles.
Multidomain and ground state configurations of two-phase vesicles.
复制标题
两相囊泡的多域和基态配置。
DOI：
10.1098/rsif.2013.0112
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Fried,Eliot
中科院分区：
文献类型：
--
作者：
Maleki,Mohsen;Fried,Eliot
一个简单的模型被用来研究两相囊泡上的脂质结构域的平衡。两类配置被认为是：多域和基态配置。对于多结构域构型，囊泡具有有限数量的相同脂质结构域。对于基态构型，囊泡完全相分离成两个共存的域。尽管具有多结构域的囊泡所包围的体积是固定的，但允许基态的囊泡所包围的体积随渗透压而变化。在实验观测的指导下，假设所有区域都是球冠。在一个多域配置中，线张力被发现减少与域的数量存在，与可能的例外时，域的数量非常小。探讨了临界渗透压和临界过剩半径对基态构型的重要性。重点放在了解这些关键量的变化与相关参数。
A simple model is used to study the equilibrium of lipid domains on two-phase vesicles. Two classes of configurations are considered: multidomain and ground state configurations. For multidomain configurations, the vesicle has a finite number of identical lipid domains. For ground state configurations, the vesicle is fully phase separated into two coexisting domains. Whereas the volume enclosed by a vesicle with multidomains is fixed, the volume enclosed by a vesicle in a ground state is allowed to vary with the osmotic pressure. Guided by experimental observations, all domains are assumed to be spherical caps. In a multidomain configuration, the line tension is found to decrease with the number of domains present, with possible exceptions when the number of domains is very small. The importance of a critical osmotic pressure and a critical excess radius on ground state configurations is explored. Emphasis is placed on understanding the variations of these critical quantities with relevant parameters.