Inhibition of the Interleukin-6 Signaling Pathway: A Strategy to Induce Immune Tolerance
Inhibition of the Interleukin-6 Signaling Pathway: A Strategy to Induce Immune Tolerance
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Interleukin-6 信号通路的抑制：诱导免疫耐受的策略
DOI：
10.1007/s12016-014-8413-3
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Chen Xing-Hua
中科院分区：
文献类型：
--
作者：
Zhang Cheng;Zhang Xing;Chen Xing-Hua
白细胞介素-6（IL-6）是一种多功能的促炎细胞因子，具有多方面的作用。IL-6信号转导通过诱导不同的途径在控制T淋巴细胞的分化和活化中起着至关重要的作用。特别地，IL-6控制Th 17细胞和调节性T（Treg）细胞之间的平衡。Treg和Th 17细胞之间的失衡被认为在各种免疫介导的疾病中发挥病理作用。IL-6产生和信号转导失调与免疫耐受相关。因此，抑制IL-6产生、受体和信号传导途径的方法是目前广泛追求的策略，以开发诱导免疫耐受的新疗法。这项调查的目的是提供一个更新的帐户，为什么IL-6抑制剂正在成为一个重要的一类药物，有可能用于诱导免疫耐受作为治疗自身免疫性疾病和移植排斥反应。此外，我们讨论了靶向IL-6在最近的实验和临床研究中对自身免疫性疾病和移植排斥反应的影响。
Interleukin-6 (IL-6) is a proinflammatory cytokine that is multifunctional, with multifaceted effects. IL-6 signaling plays a vital role in the control of the differentiation and activation of T lymphocytes by inducing different pathways. In particular, IL-6 controls the balance between Th17 cells and regulatory T (Treg) cells. An imbalance between Treg and Th17 cells is thought to play a pathological role in various immune-mediated diseases. Deregulated IL-6 production and signaling are associated with immune tolerance. Therefore, methods of inhibiting IL-6 production, receptors, and signaling pathways are strategies that are currently being widely pursued to develop novel therapies that induce immune tolerance. This survey aims to provide an updated account of why IL-6 inhibitors are becoming a vital class of drugs that are potentially useful for inducing immune tolerance as a treatment for autoimmune diseases and transplant rejection. In addition, we discuss the effect of targeting IL-6 in recent experimental and clinical studies on autoimmune diseases and transplant rejection.
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影响因子：
4.9
作者：
Silverman GJ;Carson DA
通讯作者：
Carson DA
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
20.3
作者：
Yi, Tangsheng;Chen, Ying;Zeng, Defu
通讯作者：
Zeng, Defu
DOI：
10.4049/jimmunol.1100766
发表时间：
2011-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Booth AJ;Grabauskiene S;Wood SC;Lu G;Burrell BE;Bishop DK
通讯作者：
Bishop DK