Hypocrellin B doped and pH-responsive silica nanoparticles for photodynamic therapy
Hypocrellin B doped and pH-responsive silica nanoparticles for photodynamic therapy
复制标题
用于光动力治疗的掺杂竹红菌素 B 且 pH 响应的二氧化硅纳米颗粒
DOI：
10.1007/s11426-010-3201-2
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发表时间：
2010-09-01
影响因子：
9.6
通讯作者：
Zhang BaoWen
中科院分区：
文献类型：
--
作者：
Li ZhaoBo;Wang JianGuang;Zhang BaoWen
pH响应性1O2光敏系统可作为选择性光动力学治疗（PDT）药物，靶向于多种肿瘤的酸性间质液。本研究将天然光敏剂竹红菌甲素B（HB）和pH指示剂溴甲酚紫（BCP）共包封在有机修饰的二氧化硅纳米颗粒中。BCP通过“内过滤”效应成功地调节了HB的1O2生成效率，在酸性环境中1O2生成能力比碱性环境中强得多，体外实验也证明了HB掺杂纳米颗粒对PDT杀伤肿瘤细胞的有效性.
pH-responsive1O2photosensitizing systems may serve as selective photodynamic therapy (PDT) agents by targeting the acidic interstitial fluid of many kinds of tumors. In this work, a natural and clinically used photosensitizer (Hypocrellin B, HB) and a pH indicator (Bromocresol Purple, BCP) were co-encapsulated in organically modified silica nanoparticles. BCP successfully regulated the1O2generation efficiency of HB through the “inner filter” effect, which shows much stronger1O2generation ability in an acidic than in a basic environment.In vitroexperiments also demonstrated that HB-doped nanoparticles are effective in killing tumor cells by PDT.