ACETYLCHOLINE AND LOBSTER SENSORY NEURONS
ACETYLCHOLINE AND LOBSTER SENSORY NEURONS
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DOI：
10.1113/jphysiol.1972.sp009981
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发表时间：
1972-01-01
影响因子：
5.5
通讯作者：
HERBERT, E
中科院分区：
文献类型：
--
作者：
BARKER, DL;KRAVITZ, EA;HERBERT, E
实验支持的假设，乙酰胆碱功能作为一种感觉递质在龙虾神经系统。1.几种不同的外周感觉结构将放射性胆碱纳入乙酰胆碱。相对于其他神经元件（远端外鞭毛的触角感觉器官），最富含感觉的制剂不将显著量的谷氨酸盐、酪氨酸或色氨酸掺入任何其他主要递质候选物中。2.在龙虾神经系统的许多部分，胆碱乙酰转移酶的分布与神经组织中感觉纤维的比例是平行的。3.孤立的感觉轴突含有至少500倍的胆碱乙酰转移酶每厘米的轴突传出兴奋性和抑制性纤维。4.腹神经节和根残端显示出胆碱掺入乙酰胆碱的速率下降2至8周后，切断第一和第二根双边（保持连接和第三根完整）。提取物的根桩表现出显着较低水平的胆碱乙酰转移酶2周后，这个操作。5.箭毒和阿托品部分阻断龙虾腹神经节中一个已识别的感觉突触。图像
Experiments are presented in support of the hypothesis that acetylcholine functions as a sensory transmitter in the lobster nervous system. 1. Several different peripheral sensory structures incorporate radioactive choline into acetylcholine. The preparation most enriched in sensory as opposed to other nervous elements (the antennular sense organs of the distal outer flagellum) does not incorporate significant amounts of glutamate, tyrosine or tryptophan into any of the other major transmitter candidates. 2. There is a parallel between the distribution of the enzyme choline acetyltransferase and the proportion of sensory fibres in nervous tissue from many parts of the lobster nervous system. 3. Isolated sensory axons contain at least 500 times as much choline acetyltransferase per cm of axon as do efferent excitatory and inhibitory fibres. 4. Abdominal ganglia and root stumps show a decline in the rate of incorporation of choline into acetylcholine 2 to 8 weeks after severing the first and second roots bilaterally (leaving the connectives and third roots intact). Extracts of the root stumps exhibit a significantly lower level of choline acetyltransferase 2 weeks after this operation. 5. Curare and atropine partially block an identified sensory synapse in the lobster abdominal ganglion. Images