Introns and the origin of nucleus-cytosol compartmentalization
Introns and the origin of nucleus-cytosol compartmentalization
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DOI：
10.1038/nature04531
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发表时间：
2006-03-02
期刊：
影响因子：
64.8
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Martin, W;Koonin, EV
真核细胞核的起源标志着一个重要的进化转变。我们认为，核被膜的最初功能是允许缓慢的mRNA剪接完成，因此快速的翻译只发生在具有完整阅读框架的mRNA上。在线粒体起源之后，内含子的快速、偶然的扩散被认为是形成核-胞质溶胶区室化的选择压力。
The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to go to completion so that translation, which is fast, would occur only on mRNA with intact reading frames. The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus - cytosol compartmentalization.