Effects of Experimental Sleep Restriction on Caloric Intake and Activity Energy Expenditure
Effects of Experimental Sleep Restriction on Caloric Intake and Activity Energy Expenditure
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DOI：
10.1378/chest.12-2829
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发表时间：
2013-07-01
期刊：
影响因子：
9.6
通讯作者：
Somers, Virend K.
中科院分区：
文献类型：
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作者：
Calvin, Andrew D.;Carter, Rickey E.;Somers, Virend K.
背景：流行病学研究将睡眠时间短与肥胖和体重增加联系起来。睡眠不足似乎会改变瘦素和饥饿素的循环水平，这可能会促进食欲，尽管睡眠限制对热量摄入和能量消耗的影响尚不清楚。我们试图确定8天/8晚的睡眠限制对热量摄入，活动能量消耗，循环水平的瘦素和ghrelin.Methods：我们进行了一项随机研究，通常的睡眠与睡眠限制的三分之二的正常睡眠时间为8天/8晚在医院为基础的临床研究单位。主要结果是热量摄入、活动能量消耗以及瘦素和生长激素释放肽的循环水平。睡眠限制组的卡路里摄入量增加了+559千卡/天（SD，706 kcal/d，P = .006），对照组降低118 kcal/d（SD，386 kcal/d，P = .51），净变化为+677 kcal/d（95% CI，148- 1，206 kcal/d; P = .014）。睡眠限制与活动能量消耗的变化无关（P = 0.62）。瘦素（P = 0.27）或生长激素释放肽（P = 0.21）水平无变化。结论：睡眠限制与热量消耗增加相关，活动能量消耗或瘦素和生长激素释放肽浓度无变化。增加热量摄入而不伴随任何能量消耗的增加可能会导致长期睡眠限制的人肥胖。试验注册：ClinicalTrials.gov;编号：NCT01334788; URL：www.clinicaltrials.gov
Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insufficient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.Results: Caloric intake in the sleep-restricted group increased by +559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of +677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction Was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21).Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.Trial Registration: ClinicalTrials.gov; No.: NCT01334788; URL: www.clinicaltrials.gov