Incidence and characteristics of bronchial colonisation in patient with lung cancer: A retrospective study of 388 cases
Incidence and characteristics of bronchial colonisation in patient with lung cancer: A retrospective study of 388 cases
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DOI：
10.1016/j.rmr.2010.05.020
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发表时间：
2011-03-01
影响因子：
0.6
通讯作者：
Mazieres, J.
中科院分区：
文献类型：
--
作者：
Laroumagne, S.;Salinas-Pineda, A.;Mazieres, J.
导论. - 肺癌患者经常报告支气管定植。这些定植可能会影响患者的治疗管理和预后。本研究的目的是明确肺癌患者支气管定植的发生率和性质。- 388例肺癌患者在诊断时接受了可弯曲支气管镜检查。其中，216例患者进行了细菌学、分枝杆菌学和真菌学调查。分析这些定植的类型和频率。- 在39.8%的样本中发现了潜在病原体，其中主要包括39.8%的革兰氏阴性杆菌（流感嗜血杆菌、肠杆菌属，大肠杆菌）。此外，我们发现0.9%的分枝杆菌和13.9%的白色念珠菌。在这216例进行微生物分析的患者中，患者特征和肿瘤分期与微生物定植无显著相关性。- 当诊断出肺癌时，经常报告气道定植。我们的数据表明，支气管定植应前瞻性收集，因为它在肺癌患者的管理的潜在利益。(C)2010年SPLF。由Elsevier Masson SAS出版。All rights reserved.
Introduction. - Bronchial colonisation is frequently reported in patients with lung cancer. These colonisations could influence patient therapeutic management and prognosis. The aim of our study is refine incidence and nature of bronchial colonisations in patients presenting with lung cancer.Methods. - Three hundred and eighty-eight patients with lung cancer underwent a flexible bronchoscopy at the time of diagnosis. Among them, 216 patients had a bacteriological, mycobacteriological and fungal investigation. Type and frequency of these colonisations were analyzed.Results. - Potential pathogens were found in 39.8% of samples, including mainly 39.8% of Gram-negative bacilli (Haemophilus influenzae, Enterobacter sp., Escherichia coli). In addition, we found 0.9% of mycobacteria and 13.9% of Candida albicans. Among these 216 patients where microbiological analysis was performed, patient features and tumor stage were not significantly correlated to microbial colonisation.Conclusions. - Colonisation of airways is frequently reported when a lung cancer is diagnosed. Our data suggest that bronchial colonisation should be prospectively collected due to its potential interest in the management of lung cancer patients. (C) 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.