Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdala
Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdala
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DOI：
10.1523/jneurosci.3567-04.2004
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发表时间：
2004-10-27
影响因子：
5.3
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Bauer, EP;LeDoux, JE
外侧杏仁核（LA）突触传递的长时程增强（LTP）被认为是恐惧记忆形成和保持的基础。为了探讨杏仁核可塑性的抑制性传输的作用，我们记录了从LA抑制性中间神经元在体外破伤风的丘脑-LA通路，一个主要的输入到LA参与恐惧学习之前和之后。破伤风化导致了在破伤风化丘脑通路和未破伤风化皮层通路中诱发的EPSP的LTP。这种LTP是NMDA依赖性的，并与两种途径中成对脉冲易化的减少有关。在左心房兴奋性细胞，中间神经元的LTP导致两条输入通路中GABA能IPSPs振幅的增加。最后，抑制性和兴奋性神经元之间的分离的GABA能IPSPs也可以被增强。因此，LA内抑制性传递的可塑性可能对LA介导的功能（如恐惧条件反射）有显著贡献。
Long-term potentiation (LTP) of synaptic transmission in the lateral amygdala ( LA) is believed to underlie the formation and retention of fear memories. To explore the role of inhibitory transmission in amygdala plasticity, we recorded from LA inhibitory interneurons in vitro before and after tetanization of the thalamo-LA pathway, one of the major inputs to LA involved in fear learning. Tetanization resulted in LTP of the EPSPs elicited in both the tetanized thalamic pathway and the untetanized cortical pathway to LA. This LTP was NMDA-dependent and associated with a decrease in paired-pulse facilitation in both pathways. In LA excitatory cells, LTP of interneurons resulted in an increase in the amplitude of GABAergic IPSPs in both input pathways. Finally, isolated GABAergic IPSPs between inhibitory and excitatory neurons could be potentiated as well. Plasticity of inhibitory transmission within the LA may therefore contribute significantly to LA-mediated functions, such as fear conditioning.