Synthesis of oxygen-linked 8-phenoxyl-deoxyguanosine nucleoside analogues.
Synthesis of oxygen-linked 8-phenoxyl-deoxyguanosine nucleoside analogues.
复制标题
氧连接的 8-苯氧基-脱氧鸟苷核苷类似物的合成。
DOI：
10.1002/ejoc.201100013
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发表时间：
2011
影响因子：
2.8
通讯作者：
Sturla,ShanaJ
中科院分区：
文献类型：
--
作者：
Dahlmann,HeidiA;Sturla,ShanaJ
Nucleobase adducts, which form in vivo by nucleophilic attack of nucleobases on electrophilic chemical species, can impact on the conformation and biological influences of the adducted nucleoside. Contemporary studies aim to address the occurrence and relevance of 8‐phenoxypurine adducts. However, preparative techniques for synthesizing these nucleosides have not previously been described. Reported herein is a relatively facile synthesis of 8‐dG phenol adducts using a wide variety of electron‐donating, electron‐withdrawing, and sterically demanding phenols.
