Corneal dystrophies
Corneal dystrophies
复制标题
DOI：
10.1016/j.jfo.2017.05.003
复制
发表时间：
2017-06-01
影响因子：
1.2
通讯作者：
Bourges, J. -L.
中科院分区：
文献类型：
--
作者：
Bourges, J. -L.
退化性或遗传性角膜疾病有时很难区分。角膜营养不良影响约0.09%的人口。根据其表型、基因型和为诊断收集的证据，通过IC3D分类对其进行鉴定。在实践中，眼科医生管理功能性症状，如复发性糜烂，视力丧失和弱视，恐惧症，异物感，有时疼痛和美学问题。医学治疗包括促进愈合的滴剂、软膏、高渗剂和绷带隐形眼镜。微创手术治疗用作二线治疗（光疗性角膜切除术、板层角膜切除术）。最终可能会采用更具侵入性的手术（板层或穿透性角膜移植术）。前板层或内皮角膜移植术现在比穿透性角膜移植术更受欢迎，尽管后者在某些情况下仍然是唯一可能的选择。一些罕见的营养不良需要协调和全面的医疗护理。(C)2017年Elsevier Masson SAS。All rights reserved.
Degenerative or hereditary corneal diseases are sometimes difficult to discriminate. Corneal dystrophies affect approximately 0.09% of the population. They are identified by the IC3D classification based on their phenotype, genotype and evidence gathered for their diagnosis. In practice, the ophthalmologist manages functional symptoms such as recurrent erosions, visual loss and amblyopia, photophobia, foreign body sensation, and sometimes pain and aesthetic concerns. Medical treatments consist of drops to promote healing, ointments, hyperosmotic agents and bandage contact lenses. Less invasive surgical treatments are used as second line therapy (phototherapeutic keratectomy, lamellar keratectomy). More invasive procedures may eventually be utilized (lamellar or penetrating keratoplasty). Anterior lamellar or endothelial keratoplasty are now preferred to penetrating keratoplasty, although the latter still remains the only possible option in some cases. Some rare dystrophies require coordinated and comprehensive medical care. (C) 2017 Elsevier Masson SAS. All rights reserved.