CD44 and its partners in metastasis
CD44 and its partners in metastasis
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DOI：
10.1023/a:1022931016285
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Jothy, S
中科院分区：
文献类型：
--
作者：
Jothy, S
转移的建立需要肿瘤细胞获得新的粘附和迁移特性以从原发部位迁移并定殖于远处器官。CD 44是通常在肿瘤细胞上过表达的细胞膜蛋白，并且作为细胞-细胞和细胞-细胞外基质粘附蛋白，很好地定位于促进该过程。此外，CD 44与参与运动发生和蛋白水解的其他细胞蛋白的相互作用是细胞迁移和侵袭的决定性因素。本文综述了目前对CD 44在转移中的作用的认识，以及理解这一过程如何运作的挑战。
The establishment of metastasis requires that tumor cells acquire new adhesion and migration properties to emigrate from primary sites and colonize distant organs. CD44 is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process. Furthermore the interaction of CD44 with other cellular proteins involved in motogenesis and proteolysis is a determinant factor in cell migration and invasion. This review summarizes current knowledge on the role of CD44 in metastasis, as well as the challenges on understanding how this process operates.