Genetic control of cell differentiation in platyfish-swordtail melanomas.
Genetic control of cell differentiation in platyfish-swordtail melanomas.
复制标题
鸭嘴鱼剑尾黑色素瘤细胞分化的遗传控制。
DOI：
10.1002/jez.1401960207
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
U. Vielkind
中科院分区：
文献类型：
--
作者：
U. Vielkind
在某些鱼类杂交种中，色素细胞的恶性转化是由于肿瘤基因（Tu）的存在，其作用由几个调节元件控制。这些控制基因的缺失导致tu转化细胞的快速增殖，最终导致黑色素瘤的形成。其中一个基因已被确定为分化基因（Diff），因为它似乎控制了转化色素细胞的分化。对不同Diff剂量的鱼的tu转化细胞进行光镜和电镜观察，以及对各自组织匀浆中酪氨酸酶活性的测定表明，细胞分化程度取决于基因组中Diff的剂量。结论Diff基因促进了恶性黑色素瘤细胞向良性黑色素细胞的分化。
In certain fish hybrids, malignant transformation of pigment cells is due to the presence of a tumor gene (Tu), the action of which is controlled by several regulatory elements. Absence of these controlling genes causes rapid proliferation of the Tu-transformed cells and ultimately results in melanoma formation. One of these genes has been identified as a differentiation gene (Diff), since it seems to control the differentiation of the transformed pigment cells. Light and electron microscopy of Tu-transformed cells of fish differing in the dosage of Diff, and the determination of tyrosinase activity in homogenates of the respective tissues revealed that the degree of cellular differentiation depends on the dosage of Diff present in the genome. It is concluded that the gene Diff promotes the differentiation of malignant melanoma cells into benign melanophores.