Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers
Features of evolution and expansion of modern humans, inferred from genomewide microsatellite markers
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DOI：
10.1086/375120
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发表时间：
2003-05-01
影响因子：
9.8
通讯作者：
Feldman, MW
中科院分区：
文献类型：
--
作者：
Zhivotovsky, LA;Rosenberg, NA;Feldman, MW
我们研究了全球52个人群中377个常染色体短串联重复序列基因座的变异数据，以推断人群的人口统计学历史。在二，三，和四核苷酸重复位点的变异分布不同，虽然每一类标记表现出减少人口内的遗传变异，在以下顺序：撒哈拉以南非洲，欧亚大陆，东亚，大洋洲和美洲。私人等位基因的频率也有类似的下降。在多维尺度下，属于同一主要地理区域的种群聚集在一起，某些区域允许更精细的种群分辨率。当使用逐步突变模型时，基于T-D对分歧时间的估计的种群树表明，导致目前撒哈拉以南非洲狩猎采集者种群的分支是第一个从共同祖先种群（类似于71 -142万年前）分化出来的。撒哈拉以南非洲的农业人口和离开非洲的农业人口的分支随后出现分歧，随后分支分裂为欧亚大陆，大洋洲，东亚和美洲。非洲狩猎采集者人口以及大洋洲和美洲的人口没有显示出统计上显著的增长迹象。在现代人类古代扩张的背景下，讨论了人口细分和增长的特征。
We study data on variation in 52 worldwide populations at 377 autosomal short tandem repeat loci, to infer a demographic history of human populations. Variation at di-, tri-, and tetranucleotide repeat loci is distributed differently, although each class of markers exhibits a decrease of within-population genetic variation in the following order: sub-Saharan Africa, Eurasia, East Asia, Oceania, and America. There is a similar decrease in the frequency of private alleles. With multidimensional scaling, populations belonging to the same major geographic region cluster together, and some regions permit a finer resolution of populations. When a stepwise mutation model is used, a population tree based on T-D estimates of divergence time suggests that the branches leading to the present sub-Saharan African populations of hunter-gatherers were the first to diverge from a common ancestral population (similar to71-142 thousand years ago). The branches corresponding to sub-Saharan African farming populations and those that left Africa diverge next, with subsequent splits of branches for Eurasia, Oceania, East Asia, and America. African hunter-gatherer populations and populations of Oceania and America exhibit no statistically significant signature of growth. The features of population subdivision and growth are discussed in the context of the ancient expansion of modern humans.