Genetic determinants for the racial disparities in the risk of prostate and testicular cancers.
Genetic determinants for the racial disparities in the risk of prostate and testicular cancers.
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DOI：
10.1038/s43856-022-00205-5
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发表时间：
2022-11-02
期刊：
影响因子：
--
通讯作者：
Zhu, Yong
中科院分区：
文献类型：
--
作者：
Uzamere, Ivie;Wang, Yinqiao;Zheng, Tongzhang;Zhu, Yong
以前观察到，与欧洲血统相比，非洲血统男性的前列腺癌发病率在全球范围内更高，而睾丸癌的发病率更低。然而，解释这些观察结果的潜在机制在很大程度上是未知的。目前的研究分析了先前报道的与前列腺癌或睾丸癌相关的SNPs，以检查风险等位基因频率是否可以帮助我们了解非洲血统和欧洲血统男性的发病率差异。采用t检验和回归分析。这里我们表明，与欧洲血统的男性相比，非洲血统的男性更有可能患有前列腺癌的风险等位基因，而不太可能患有睾丸癌的风险等位基因。我们的发现表明，遗传因素可能在前列腺癌和睾丸癌风险的种族差异中发挥重要作用。据观察，与欧洲血统的男性相比，非洲血统的男性前列腺癌的发病率更高，而睾丸癌的发病率更低。然而，人们对解释这些观察结果的潜在机制知之甚少。目前的研究比较了两个种族之间与前列腺癌或睾丸癌风险相关的所有基因改变的频率。我们的发现表明，这两个群体之间基因改变频率的差异可能有助于解释前列腺癌和睾丸癌风险的种族差异。Uzamere、Wang等人的研究成果。寻求了解前列腺癌和睾丸癌风险中种族差异的遗传决定因素。作者确定了非洲裔和欧洲裔男性之间已知的前列腺癌/睾丸癌相关变异的平均风险等位基因频率的差异。
A worldwide higher incidence of prostate cancer and lower incidence of testicular cancer in men of African ancestry compared to European ancestry has been observed previously. However, underlying mechanisms accounting for these observations are largely unknown. The current study analyzed previously reported SNPs associated with either prostate cancer or testicular cancer to examine whether the risk allele frequency could help us understand the observed incidence disparities in men of African ancestry and European ancestry. Both t-test and regression analysis were performed. Here we show that men of African ancestry are more likely to have risk alleles of prostate cancer and less likely to have risk alleles of testicular cancer compared to men of European ancestry. Our findings suggest that genetic factors may play an important role in the racial disparities in the risk of prostate and testicular cancers. It has been observed that men of African ancestry have a higher incidence of prostate cancer and lower incidence of testicular cancer compared to men of European ancestry. However, little is known about underlying mechanisms accounting for these observations. The current study compares frequencies of all genetic alterations associated with risks of prostate cancer or testicular cancer between the two racial groups. Our findings suggest that differences in the frequencies of genetic alterations between the groups may help to explain the racial disparities in the risk of prostate and testicular cancers. Uzamere, Wang et al. seek to understand the genetic determinants of racial disparities in the risk of prostate and testicular cancers. The authors identify differences in average risk allele frequency for known prostate/testicular cancer-associated variants between men of African descent and men of European descent.
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