Biocompatible 2D Titanium Carbide (MXenes) Composite Nanosheets for pH-Responsive MRI-Guided Tumor Hyperthermia
Biocompatible 2D Titanium Carbide (MXenes) Composite Nanosheets for pH-Responsive MRI-Guided Tumor Hyperthermia
复制标题
用于 pH 响应 MRI 引导肿瘤热疗的生物相容性二维碳化钛 (MXenes) 复合纳米片
DOI：
10.1021/acs.chemmater.7b02441
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发表时间：
2017-10-24
影响因子：
8.6
通讯作者：
Chen, Yu
中科院分区：
文献类型：
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作者：
Dai, Chen;Lin, Han;Chen, Yu
二维（2D） MXenes的出现大大拓宽了二维材料的家族成员和用途，但基于MXenes的复合材料的合理设计及其在治疗生物医学中的具体应用仍然具有挑战性。在这项工作中，我们首次报道了基于Ti3C2的复合MXene （MnOx/Ti3C2）的精心设计，用于高效治疗癌症。这些MnOx/Ti3C2复合MXenes是通过触发简单的氧化还原反应在Ti3C2表面原位生长小的MnOx纳米片来构建的。这些MnOx/Ti3C2复合MXenes已被开发为多功能治疗剂，用于有效的磁共振（MR）和光声（PA）双模成像引导光热治疗（PTT）癌症。特别是将MnOx组分修饰在MnOx/Ti3C2上，实现了肿瘤独特的肿瘤微环境响应t1加权MR成像，具有较高的光热转换性能。
The emerging of two-dimensional (2D) MXenes significantly broadens the family members and versatile applications of 2D materials, but the rational design of MXene-based composites and their specific applications in theranostic biomedicine are still challenging. In this work, we report, for the first time, on the elaborate design of the Ti3C2-based composite MXene (MnOx/Ti3C2) for highly efficient theranostic applications against cancer. These MnOx/Ti3C2 composite MXenes have been constructed by triggering a simple redox reaction to in situ grow small MnOx nanosheets on the surface of Ti3C2. These MnOx/Ti3C2 composite MXenes have been developed as multifunctional theranostic agents for efficient magnetic resonance (MR) and photoacoustic (PA) dual-modality imaging-guided photothermal therapy (PTT) against cancer. Especially, the decoration of the MnOx component onto MnOx/Ti3C2 realizes the unique tumor microenvironment-responsive T1-weighted MR imaging of tumors, and the high photothermal-conversion perform...