Lymphadenopathy in homosexual men. Morbid anatomy with clinical and immunologic correlations.
Lymphadenopathy in homosexual men. Morbid anatomy with clinical and immunologic correlations.
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同性恋男性的淋巴结肿大。
DOI：
10.1093/ajcp/79.5.559
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发表时间：
1983
影响因子：
3.5
通讯作者：
G. Newell
中科院分区：
文献类型：
--
作者：
L. Guarda;James J. Butler;P. Mansell;E. Hersh;J. Reuben;G. Newell
本文报告11例青年男同性恋者淋巴结肿大3个月以上，多数伴有发热和体重减轻的病例。10例患者主要表现为反应性滤泡和窦状隙增生。髓窦充满与中性粒细胞相关的单形圆形窦状细胞。在10例患者中，1例肉芽肿填充了被膜下窦，尤其是。另一个病人表现为淋巴细胞耗尽的淋巴结，缺乏生发中心和突出的血管骨架;后者的特征使得很难将其与卡波西肉瘤的淋巴结形式区分开来。所有患者都有性乱史，并使用“娱乐性”药物。10例患者中有9例存在细胞免疫缺陷和T细胞辅助/抑制比值倒置。唯一一个细胞免疫正常的病人有淋巴结肉芽肿。所有患者的体液免疫均正常。
This is a study of the histopathologic features of lymph nodes removed from eleven young, homosexual men, all of whom presented with lymph node enlargement of more than 3 months' duration, accompanied, in the majority of cases, by fever and weight loss. Reactive follicular and sinusoidal hyperplasia were the main findings in 10 patients. The medullary sinuses were packed with monomorphic round sinusoidal cells associated with neutrophils. In one of the 10 patients, granulomas packed the subcapsular sinuses, especially. Another patient presented with lymphoid-depleted nodes with absent germinal centers and a prominent vascular skeleton; this latter feature made it difficult to distinguish this picture from the nodal form of Kaposi's sarcoma. All patients had a history of sexual promiscuity and used "recreational" drugs. Nine of 10 patients had deficient cellular immunity and inverted T-cell helper/suppressor ratios. The only patient with normal cellular immunity had nodal granulomas. Humoral immunity was normal in all patients.