Predictive genetic testing for hereditary breast and ovarian cancer: psychological distress and illness representations 1 year following disclosure.
Predictive genetic testing for hereditary breast and ovarian cancer: psychological distress and illness representations 1 year following disclosure.
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DOI：
10.1007/s10897-005-1371-4
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发表时间：
2005-10-01
影响因子：
1.9
通讯作者：
Legius, E
中科院分区：
文献类型：
--
作者：
Claes, E;Evers-Kiebooms, G;Legius, E
这项前瞻性研究评估了68名未受影响的女性(34名携带者/34名非携带者)的情绪功能和疾病表现，当在多学科方法中提供BRCA1/2突变预测测试一年后。携带者对乳腺癌的主观风险知觉高于非携带者。没有接受预防性卵巢切除术的携带者患卵巢癌的风险最高。在乳腺癌和卵巢癌的严重性和控制感方面，携带者和非携带者之间没有发现差异。平均痛苦程度在正常范围内。只有很少的女性表现出总体的临床升高的痛苦模式。从测试前到测试后，非携带者的癌症特有的痛苦和状态焦虑显着减少，而总体痛苦几乎保持不变。携带者组的苦恼没有显着变化，只有卵巢癌苦恼从测试前到测试后显着降低。我们的研究没有揭示在多学科方法的背景下提供预测性测试的不利影响。
This prospective study evaluates emotional functioning and illness representations in 68 unaffected women (34 carriers/34 noncarriers) 1 year after predictive testing for BRCA1/2 mutations when offered within a multidisciplinary approach. Carriers had higher subjective risk perception of breast cancer than noncarriers. Carriers who did not have prophylactic oophorectomy had the highest risk perception of ovarian cancer. No differences were found between carriers and noncarriers regarding perceived seriousness and perceived control of breast and ovarian cancer. Mean levels of distress were within normal ranges. Only few women showed an overall pattern of clinically elevated distress. Cancer-specific distress and state-anxiety significantly decreased in noncarriers from pre- to posttest while general distress remained about the same. There were no significant changes in distress in the group of carriers except for ovarian cancer distress which significantly decreased from pre- to posttest. Our study did not reveal adverse effects of predictive testing when offered in the context of a multidisciplinary approach.