Gonadotropin Therapy of Female Infertility
Gonadotropin Therapy of Female Infertility
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促性腺激素治疗女性不孕症
DOI：
10.1159/000299438
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
G. Bettendorf
中科院分区：
文献类型：
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作者：
R. Zimmermann;B. Soor;W. Braendle;F. Lehmann;H. Weise;G. Bettendorf
本报告基于 416 名不孕女性患者，她们接受了 1,033 个周期的促性腺激素治疗。 28.6%的患者在hMG/hCG治疗后受孕。 79.8% 的妊娠中，生下的是健康的孩子。 20.2%的病例发生自然流产或早产。双胞胎率为28.6%，三胞胎率为5.5%。大多数堕胎发生在妊娠早期（52.2%）。未见畸形。不同诊断组的妊娠率存在显着差异：促性腺激素分泌不足的闭经为 44.4%，促性腺激素正常的闭经为 50%，无排卵周期为 22%，黄体功能不全为 14.8%。这四组的流产率如下：促性腺激素低下闭经25%，促性腺激素正常闭经14.7%，无排卵周期4.8%，黄体功能不全36.3%。对四组的治疗周期进行详细分析：hMG/hCG安瓿数量从黄体功能不全患者的21.4安瓿增加到低促性腺激素闭经患者的47.7安瓿。黄体功能不全患者的非活跃期为 5.6 天，而促性腺激素不足的闭经患者则为 8.5 天。自发性子宫出血患者在排卵前后和黄体期的雌激素值要低得多。这些患者中过度刺激综合征的发生率较低。黄体功能不全患者的妊娠比例从第一次的 8.1% 下降
This report is based on 416 infertile female patients, who were treated for 1,033 cycles with gonadotropins. 28.6% of the patients conceived after hMG/hCG treatment. In 79.8% of these pregnancies, healthy children were born. Spontaneous abortion or premature birth occurred in 20.2% of the cases. The twin rate was 28.6%, the triplet rate 5.5%. Most of the abortions occurred in the first trimester (52.2%). No malformations were seen. The pregnancy rate showed striking differences in the various diagnostic groups: hypogonadotropic amenorrhea 44.4%, normogonadotropic amenorrhea 50%, anovulatory cycles 22%, corpus luteum insufficiency 14.8%. The abortion rates for these four groups were as follows: hypogonadotropic amenorrhea 25%, normogonadotropic amenorrhea 14.7 %, anovulatory cycles 4.8 %, corpus luteum insufficiency 36.3 %. A detailed analysis of the treatment cycles is given for the four groups: the number of ampoules of hMG/hCG increased from 21.4 ampoules in patients with corpus luteum insufficiency to 47.7 ampoules in patients with hypogonadotropic amenorrhea. The inactive phase increased from 5.6 days in patients with corpus luteum insufficiency to 8.5 days in patients with hypogonadotropic amenorrhea. Estrogen values around the time of ovulation and in the corpus luteum phase were much lower in patients with spontaneous uterine bleedings. Hyperstimulation syndrome occurred less frequently in these patients. The percentage of pregnancies decreased in patients with corpus luteum insufficiency from 8.1 % in the first