WEIGHT-GAIN - A SIDE-EFFECT OF TRICYCLIC ANTIDEPRESSANTS
WEIGHT-GAIN - A SIDE-EFFECT OF TRICYCLIC ANTIDEPRESSANTS
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DOI：
10.1016/0165-0327(84)90031-4
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发表时间：
1984-01-01
影响因子：
6.6
通讯作者：
STERN, WC
中科院分区：
文献类型：
--
作者：
BERKEN, GH;WEINSTEIN, DO;STERN, WC
对40名来自私人精神科诊所的抑郁症患者的体重和食欲进行了评估，这些患者接受了低剂量-中等剂量的三环类抗抑郁药物治疗。阿米替林(最大剂量150 mg/d)、去甲替林(最大剂量50 mg/d)和丙咪嗪(最大剂量80 mg/d)平均给药6mo。关于治疗的问题。平均体重增加1.3-2.9磅/月，这导致平均总体重增加3-16磅，这取决于药物、剂量和持续时间。这些体重的增加是随着时间的推移呈线性增长的，同时伴随着对甜食偏好的显著增加。最终，体重过度增加是导致停止治疗的最常见原因，发生在1/2的患者中。停药后体重显著下降。研究结果表明，长期服用低至中等剂量的三环类抗抑郁药经常会导致体重显著增加，并可能严重干扰提供长期维持治疗的能力。
Body weight and appetite were evaluated in 40 depressed outpatients from a private psychiatric practice who were receiving low-modest doses of tricyclic antidepressants. Amitriptyline (maximum of 150 mg/day), nortriptyline (maximum of 50 mg/day), and imipramine (maximum of 80 mg/day) were given for an average of 6 mo. of treatment. There was a mean weight increase of 1.3-2.9 lbs/mo., which led to an average total weight gain of 3-16 lbs, depending on drug, dose and duration. These weight increases were linear over time and were accompanied by marked increases in the preference for sweets. Ultimately, excessive weight gain was the most common cause of discontinuation of treatment, occurring in 1/2 of the patients. Significant weight loss occurred upon discontinuation of drug. The findings show that chronic administration of low-modest doses of tricyclic antidepressants frequently cause considerable weight gain and can significantly interfere with the ability to provide long-term maintenance therapy.