The effect of intrathecal midazolam on post-operative pain.
The effect of intrathecal midazolam on post-operative pain.
复制标题
鞘内注射咪达唑仑对术后疼痛的影响。
DOI：
--
复制
发表时间：
1996
影响因子：
3.6
通讯作者：
M. Bellamy
中科院分区：
文献类型：
--
作者：
J. Valentine;Gordon Lyons;M. Bellamy
评估了鞘内咪达唑仑单独给药和与鞘内二乙酰吗啡联合给药时用作术后镇痛剂的情况。选择52例腰麻下择期剖腹产的患者，随机分配接受布比卡因（B），布比卡因与二乙酰吗啡（BD），布比卡因与咪达唑仑（BM）或所有三种（BMD）通过鞘内注射。术后，两组之间的视觉模拟评分（VAS）、镇静或术后恶心和呕吐（PONV）无差异。与其他组相比，B组患者自控镇痛系统（PCAS）的使用率显著较高。瘙痒症是常见的患者接受二乙酰吗啡（BMD和BD）。未发现归因于咪达唑仑的副作用。鞘内注射此剂量的咪达唑仑似乎是安全的，并具有临床可检测的镇痛特性。有效镇痛的持续时间似乎很短。
Intrathecal midazolam for use as a post-operative analgesic when given alone and in conjunction with intrathecal diamorphine was assessed. Fifty-two patients scheduled for elective Caesarean section under spinal anaesthesia were randomly allocated to receive either bupivacaine (B), bupivacaine with diamorphine (BD), bupivacaine with midazolam (BM) or all three (BMD) by intrathecal injection. Post-operatively, no differences in visual analogue score (VAS), sedation or post-operative nausea and vomiting (PONV) could be demonstrated between groups. Patient-controlled analgesia system (PCAS) usage was significantly greater in group B when compared with the other groups. Pruritus was commoner in patients receiving diamorphine (BMD & BD). No side effects attributable to midazolam were identified. Intrathecal midazolam at this dose appears safe and has clinically detectable analgesic properties. The duration of useful analgesia appears to be short-lived.