Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19.
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19.
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DOI：
10.3389/fimmu.2021.686029
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发表时间：
2021
影响因子：
7.3
通讯作者：
Tleyjeh IM
中科院分区：
文献类型：
--
作者：
Ramakrishnan RK;Kashour T;Hamid Q;Halwani R;Tleyjeh IM
冠状病毒病2019（COVID-19）自出现以来已超过一年，由于缺乏治疗方案，该疾病仍然迫在眉睫。令这一负担雪上加霜的是，相当一部分从急性COVID-19感染中康复的患者报告了挥之不去的症状，导致严重残疾和日常生活活动受损。这些患者被认为患有所谓的“慢性”或“长期”COVID-19或COVID-19急性后后遗症，经历这种综合征的患者被称为COVID-19长途运输者。尽管从感染中恢复，但持续存在的非典型慢性症状，包括极度疲劳、呼吸急促、关节痛、脑雾、焦虑和抑郁，可能持续数月，这意味着潜在的疾病病理学在疾病的急性表现之后仍然存在。与病毒本身的直接影响相反，对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的免疫反应被认为是这些持久症状出现的主要原因，可能是通过促进持续的炎症过程。在这篇综述中，我们假设了这些持续和长期影响的潜在免疫学机制，并描述了COVID-19的多器官长期表现。
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still looming large with a paucity of treatment options. To add to this burden, a sizeable subset of patients who have recovered from acute COVID-19 infection have reported lingering symptoms, leading to significant disability and impairment of their daily life activities. These patients are considered to suffer from what has been termed as “chronic” or “long” COVID-19 or a form of post-acute sequelae of COVID-19, and patients experiencing this syndrome have been termed COVID-19 long-haulers. Despite recovery from infection, the persistence of atypical chronic symptoms, including extreme fatigue, shortness of breath, joint pains, brain fogs, anxiety and depression, that could last for months implies an underlying disease pathology that persist beyond the acute presentation of the disease. As opposed to the direct effects of the virus itself, the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is believed to be largely responsible for the appearance of these lasting symptoms, possibly through facilitating an ongoing inflammatory process. In this review, we hypothesize potential immunological mechanisms underlying these persistent and prolonged effects, and describe the multi-organ long-term manifestations of COVID-19.
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
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影响因子：
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64.8
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DOI：
10.4103/ijri.ijri_469_16
发表时间：
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期刊：
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影响因子：
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影响因子：
7.3
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通讯作者：
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