BACTERICIDAL ACTIVITY OF HUMAN MILK LEUKOCYTES
BACTERICIDAL ACTIVITY OF HUMAN MILK LEUKOCYTES
复制标题
人乳白细胞的杀菌活性
DOI：
10.1111/j.1651-2227.1981.tb07178.x
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
V. Reddy
中科院分区：
文献类型：
--
作者：
P. Bhaskaram;V. Reddy
抽象的。Bhaskaram，P.和Vinodini Reddy(印度海得拉巴国家营养研究所)。人乳白细胞的杀菌活性。儿科学报，70：87,1981。-对74名处于哺乳期不同阶段的妇女的母乳样本进行了白细胞浓度和杀菌活性分析。初乳中白细胞总数为5000个/mm~3，与循环中的浓度相近。随着哺乳期的建立，白细胞浓度有所下降，在前3个月后，成熟乳中的平均白细胞数约为2000个/mm3。多形细胞和单核白细胞占细胞总数的90-95%，其余为淋巴细胞。牛奶白细胞的杀菌活性与循环白细胞的杀菌活性相似，与哺乳期无关。这些结果表明，母乳中含有丰富的活白细胞，这些细胞可能对婴儿的感染具有保护作用。在营养良好和营养不良的妇女中，总白细胞浓度及其杀菌能力相似，表明牛奶中的保护因素不受母亲营养状况的影响。
Abstract. Bhaskaram, P. and Vinodini Reddy (National Institute of Nutrition, Hyderabad, India). Bactericidal activity of human milk leukocytes. Acta Paediatr Scand, 70: 87, 1981.–Breast milk samples obtained from 74 women, at different stages of lactation, were analysed for leukocyte concentration and their bactericidal activity. The total leukocyte count in colostrum was 5000/mm3 a concentration which is similar to that in circulation. As lactation became established, there was a drop in leukocyte concentration and the average count in mature milk was around 2000/mm3 after the first 3 months. Polymorphs and mononuclear leukocytes together constituted 90–95 % of the cells and the rest were lymphocytes. Bactericidal activity of milk leukocytes was similar to that of circulating leukocytes, irrespective of the stage of lactation. These results indicate that breast milk is rich in living leukocytes and that these cells may have a protective role against infection in the infant. The total leukocyte concentration as well as their bactericidal capacity were similar in well nourished and undernourished women suggesting that the protective factors in milk are not influenced by nutritional status of the mother.