Are the origins of adult arthritis seeded during embryonic development?
Are the origins of adult arthritis seeded during embryonic development?
复制标题
成人关节炎的起源是在胚胎发育过程中播种的吗？
DOI：
10.1038/s41584-023-00911-x
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Hackland A
中科院分区：
文献类型：
--
作者：
Hackland A
滑膜组织成纤维细胞的表型和功能异质性已得到很好的描述，而在成人关节中建立这种多样化成纤维细胞库的细胞和分子机制仍不清楚。滑膜成纤维细胞库的命运是什么时候决定的，成年后关节炎的发展有什么后果？
The phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?