Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies.
Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies.
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DOI：
10.1186/1471-244x-13-110
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发表时间：
2013-04-09
期刊：
影响因子：
4.4
通讯作者：
Brooks SJ
中科院分区：
文献类型：
--
作者：
Titova OE;Hjorth OC;Schiöth HB;Brooks SJ
结构成像研究表明饮食失调患者的脑组织异常，但尚未进行定量分析。在9项基于体素的形态测定（VBM）研究的全球和区域荟萃分析中，共有228名进食障碍参与者（目前患有神经性厌食症）和240名年龄匹配的健康对照者，我们使用全球和区域分析比较了脑容量。神经性厌食症（AN）患者的灰质（效应量=-0.66）和白色物质（效应量=-0.74）总体减少，脑脊液增加（效应量= 0.98），左侧下丘脑、左侧顶叶下叶、右侧豆状核和右侧尾状核局部减少，无显著增加。大脑半球偏侧化没有显着差异被发现。全球和区域的荟萃分析表明，过度限制饮食神经性厌食症与结构性大脑变化类似的临床症状相一致。
Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done. In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses. Anorexia nervosa (AN) patients have global reductions in gray (effect size = −0.66) and white matter (effect size = −0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found. Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms.