Deficient inhibition as a marker for familial ADHD
Deficient inhibition as a marker for familial ADHD
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DOI：
10.1176/appi.ajp.158.11.1884
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发表时间：
2001-11-01
影响因子：
17.7
通讯作者：
Schachar, R
中科院分区：
文献类型：
--
作者：
Crosbie, J;Schachar, R
目的：作者调查了是否缺乏抑制控制，停止信号范式，划定一个家族亚组的注意缺陷多动障碍（ADHD）。方法：受试者是54 ADHD儿童定义为具有良好或不良的抑制（停止信号范式性能的基础上）和26名健康对照儿童。结果：ADHD患儿家庭中抑制能力差的儿童（48.1%）比抑制能力好的儿童（18.5%）或健康对照儿童（7.7%）的ADHD患病率高，且与ADHD患儿家庭的神经生物学和心理社会学危险因素有关。神经生物学或心理社会风险无显着差异被发现为three groups.Conclusions：抑制不足划定了ADHD的家族亚型。心理社会和神经生物学因素不能解释良好抑制组的纳入，也不能与抑制联合作用，增加不良抑制组的ADHD风险。这项研究表明，认知措施，如抑制的实验室测量可以作为遗传分析的表型标记。
Objective: The authors investigated whether deficient inhibitory control, as measured by the stop-signal paradigm, delineates a familial subgroup of attention deficit hyperactivity disorder (ADHD).Method: Subjects were 54 ADHD children defined as having poor or good inhibition (on the basis of stop-signal paradigm performance) and 26 healthy comparison children. Family history of ADHD and measures of neurobiological and psychosocial risk were compared among the three groups.Results: ADHD was significantly more prevalent in the families of the children with ADHD who exhibited poor inhibition (48.1%) than in the families of those exhibiting good inhibition (18.5%) or in the families of healthy comparison children (7.7%). No differences in neurobiological or psychosocial risk were found for the three groups.Conclusions: Deficient inhibition delineates a familial subtype of ADHD. Psychosocial and neurobiological factors did not account for inclusion in the good inhibition group and did not act conjointly with inhibition to increase the risk for ADHD in the poor inhibition group. This study demonstrates that cognitive measures such as a laboratory measure of inhibition can serve as phenotype markers for genetic analyses.