Field studies on the immune response to 17D yellow fever virus - Relation to virus substrain dose, and route of inoculation
Field studies on the immune response to 17D yellow fever virus - Relation to virus substrain dose, and route of inoculation
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DOI：
10.1093/oxfordjournals.aje.a118875
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发表时间：
1943-09-01
影响因子：
--
通讯作者：
Da Cunha, JF
中科院分区：
文献类型：
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作者：
Fox, JP;Kossobudzki, SL;Da Cunha, JF
经验。据报道，实质性扩大了 17D 病毒在黄热病疫苗接种中的使用基础。这些外籍人士。能够更详细地界定实现令人满意的结果的必要条件，并在必要条件得到满足时重申这些结果的令人满意的性质。发现 17D 亚株具有非常相似的抗原特征。还获得了证据表明，小剂量的病毒可能比大剂量的病毒产生更好的免疫反应。然而，为了使接种疫苗的人获得满意的比例，常规疫苗接种剂量应包含不少于约。老鼠500。 14 岁以下个体的免疫反应与年龄直接相关。血清的平均保护能力随着供体年龄的增长而增加。人类对皮内或肌肉内注射的敏感性。接种的病毒大于接种病毒的亚切割的病毒。但差异不足以超过亚切割的优点。当使用足够的体积时的路线。
Expts. materially broadening the basis for use of 17D virus in vaccinating against yellow fever are reported. These expts. make it possible to define in greater detail the conditions necessary for the achievement of satisfactory results and reaffirm the satisfactory nature of these results when the necessary conditions have been met. Substrains of 17D were found to be of closely similar antigenic character. Evidence that small virus doses might result in a better immune response than larger doses was also obtained. However, in order to immunize a satisfactory percentage of persons vaccinated, the routine vaccinating dose should contain not less than approx. 500 for mice. The immune response of individuals up to age 14 is directly related to age. The average protective capacity of the sera increases with the age of the donor. Human susceptibility to intra-dermally or intramusc. inoculated virus is greater than that to virus administered subcut.. but the differences are not sufficient to outweigh the advantages of the subcut. route when an adequate volume is employed.